Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types

Abstract Background Pharmacotherapy for most psychiatric conditions was developed from serendipitous observations of benefit drugs prescribed different reasons. An algorithmic approach to formulating pharmacotherapy is proposed, based upon which combination changed activities by brain cell-types dominant any particular condition, because those contain and surrogate genetic, metabolic environmental information, that has affected their function. The algorithm performs functions some or all the several available drugs: clemastine, dantrolene, erythropoietin, fingolimod, fluoxetine, lithium, memantine, minocycline, pioglitazone, piracetam, riluzole Procedures/findings Bipolar disorder, major depressive schizophrenia, Alzheimer’s disease, post-traumatic stress illustrate algorithm; them, literature reviews show no single altered accounts cases; but they identify, each occurs frequently, i.e., dominates, as compared with other possible combinations. Knowing in a permits formulation therapy combinations taken above list. percentage patients who might therapy, depends frequency condition. Conclusions cell types conditions, an algorithmically formulated, rationally-based treatment. Different studies same condition often produce discrepant results; be correct, identical clinical phenotypes result impaired cell-types, thus producing results. Clinical trials would validate both proposed concept choice drugs.